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1

Biosynthetic Gene Cluster of the Glycopeptide Antibiotic Teicoplanin: Characterization of Two Glycosyltransferases and the Key Acyltransferase

Tsung-Lin Li, Fanglu Huang, Stephen F Haydock, Tatiana Mironenko, Peter F Leadlay, Jonathan B Spencer

Journal:

Chemistry & Biology

Year:

2004

Language:

english

File:

PDF, 533 KB

english, 2004

2

The Gene Cluster for Fluorometabolite Biosynthesis in Streptomyces cattleya: A Thioesterase Confers Resistance to Fluoroacetyl-Coenzyme A

Fanglu Huang, Stephen F. Haydock, Dieter Spiteller, Tatiana Mironenko, Tsung-Lin Li, David O'Hagan, Peter F. Leadlay, Jonathan B. Spencer

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 429 KB

english, 2006

3

Mammalian Fatty Acid Synthase: Closure on a Textbook Mechanism?

Peter Leadlay, Abel Baerga-Ortiz

Journal:

Chemistry & Biology

Year:

2003

Language:

english

File:

PDF, 197 KB

english, 2003

4

10.1038/46829

Long, Paul F., Bisang, Christian, Corte´s, Jesús, Westcott, James, Crosby, John, Matharu, Anne-Lise, Cox, Russell J., Simpson, Thomas J., Staunton, James, Leadlay, Peter F.

Journal:

Year:

1999

Language:

english

File:

PDF, 196 KB

english, 1999

5

How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 å resolution

Filippo Mancia, Nicholas H Keep, Atsushi Nakagawa, Peter F Leadlay, Sean McSweeney, Bjarne Rasmussen, Peter Bö secke, Olivier Diat, Philip R Evans

Journal:

Year:

1996

Language:

english

File:

PDF, 1.52 MB

english, 1996

6

Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes

Parascandolo, James S., Havemann, Judith, Potter, Helen K., Huang, Fanglu, Riva, Elena, Connolly, Jack, Wilkening, Ina, Song, Lijiang, Leadlay, Peter F., Tosin, Manuela

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 864 KB

english, 2016

7

Isoafricanol synthase from Streptomyces malaysiensis

Rabe, Patrick, Samborskyy, Markiyan, Leadlay, Peter F., Dickschat, Jeroen S.

Journal:

Organic & Biomolecular Chemistry

Year:

2017

Language:

english

File:

PDF, 2.64 MB

english, 2017

8

Directed Accumulation of Anticancer Depsipeptides by Characterization of Neoantimycins Biosynthetic Pathway and an NADPH-dependent Reductase

Zhou, Yongjun, Lin, Xiao, Williams, Simon R., Liu, Liyun, Shen, Yaoyao, Wang, Shu-Ping, Sun, Fan, Xu, Shihai, Deng, Hai, Leadlay, Peter F, Lin, Hou-Wen

Journal:

ACS Chemical Biology

Year:

2018

Language:

english

File:

PDF, 918 KB

english, 2018

9

Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry

Paul J. Gates, Gordon C. Kearney, Raymond Jones, Peter F. Leadlay, James Staunton

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 66 KB

english, 1999

10

Structural elucidation studies of erythromycins by electrospray tandem mass spectrometry II

Gordon C. Kearney, Paul J. Gates, Peter F. Leadlay, James Staunton, Raymond Jones

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 117 KB

english, 1999

11

Structural elucidation studies of polyketide tetrasubstituted δ-lactones by gas chromatography/tandem mass spectrometry and electrospray mass spectrometry

Kira J. Weissman, Gordon C. Kearney, Peter F. Leadlay, James Staunton

Journal:

Rapid Communications in Mass Spectrometry

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

12

Die Thioesterase der Polyketid-Synthase von Erythromycin: Einfluß der Acylkettenstruktur auf den Abkopplungsmechanismus der Substratanaloga von der Acyl-Enzym-Zwischenstufe

Kira J. Weissman, Cameron J. Smith, Ulf Hanefeld, Ranjana Aggarwal, Matthew Bycroft, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

1998

Language:

german

File:

PDF, 100 KB

german, 1998

13

The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates

Kira J. Weissman, Cameron J. Smith, Ulf Hanefeld, Ranjana Aggarwal, Matthew Bycroft, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

1998

Language:

english

File:

PDF, 95 KB

english, 1998

14

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Philip A. S. Lowden, Barrie Wilkinson, Günter A. Böhm, Sandeep Handa, Heinz G. Floss, Peter F. Leadlay, James Staunton

Journal:

Angewandte Chemie

Year:

2001

Language:

english

File:

PDF, 76 KB

english, 2001

15

Origin and True Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Philip A. S. Lowden, Barrie Wilkinson, Günter A. Böhm, Sandeep Handa, Heinz G. Floss, Peter F. Leadlay, James Staunton

Journal:

Angewandte Chemie International Edition

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

16

Die Startereinheit der Rapamycin-Polyketid-Synthase

Philip A. S. Lowden, Dr. Günter A. Böhm, Dr. James Staunton, Dr. Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

1996

Language:

german

File:

PDF, 344 KB

german, 1996

17

Intermediates Released from a Polyether-Producing Polyketide Synthase Provide Insight into the Mechanism of Oxidative Cyclization

Zoë A. Hughes-Thomas, Christian B. W. Stark, Ines U. Böhm, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 164 KB

english, 2003

18

Isolation and Characterization of Pre-rapamycin, the First Macrocyclic Intermediate in the Biosynthesis of the Immunosuppressant Rapamycin by S. hygroscopicus

Matthew A. Gregory, Sabine Gaisser, Rachel E. Lill, Hui Hong, Rose M. Sheridan, Barrie Wilkinson, Hrvoje Petkovic, Alison J. Weston, Isabelle Carletti, Huai-Lo Lee, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

2004

Language:

english

File:

PDF, 106 KB

english, 2004

19

Mutasynthesis of Rapamycin Analogues through the Manipulation of a Gene Governing Starter Unit Biosynthesis

Matthew A. Gregory, Hrvoje Petkovic, Rachel E. Lill, Steven J. Moss, Barrie Wilkinson, Sabine Gaisser, Peter F. Leadlay, Rose M. Sheridan

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 273 KB

english, 2005

20

Accumulation of an E,E,E-Triene by the Monensin-Producing Polyketide Synthase when Oxidative Cyclization is Blocked

Apoorva Bhatt, Christian B. W. Stark, Barbara M. Harvey, Andrew R. Gallimore, Yuliya A. Demydchuk, Jonathan B. Spencer, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 119 KB

english, 2005

21

Insights into Lasalocid A Ring Formation by Chemical Chain Termination In Vivo

Dr. Manuela Tosin, Luke Smith, Prof. Peter F. Leadlay

Journal:

Angewandte Chemie

Year:

2011

Language:

english

File:

PDF, 616 KB

english, 2011

22

The Nature of the Starter Unit for the Rapamycin Polyketide Synthase

Philip A. S. Lowden, Dr. Günter A. Böhm, Dr. James Staunton, Dr. Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

1996

Language:

english

File:

PDF, 312 KB

english, 1996

23

Intermediates Released from a Polyether-Producing Polyketide Synthase Provide Insight into the Mechanism of Oxidative Cyclization

Zoë A. Hughes-Thomas, Christian B. W. Stark, Ines U. Böhm, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 165 KB

english, 2003

24

Isolation and Characterization of Pre-rapamycin, the First Macrocyclic Intermediate in the Biosynthesis of the Immunosuppressant Rapamycin by S. hygroscopicus

Matthew A. Gregory, Sabine Gaisser, Rachel E. Lill, Hui Hong, Rose M. Sheridan, Barrie Wilkinson, Hrvoje Petkovic, Alison J. Weston, Isabelle Carletti, Huai-Lo Lee, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 107 KB

english, 2004

25

Mutasynthesis of Rapamycin Analogues through the Manipulation of a Gene Governing Starter Unit Biosynthesis

Matthew A. Gregory, Hrvoje Petkovic, Rachel E. Lill, Steven J. Moss, Barrie Wilkinson, Sabine Gaisser, Peter F. Leadlay, Rose M. Sheridan

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 274 KB

english, 2005

26

Accumulation of an E,E,E-Triene by the Monensin-Producing Polyketide Synthase when Oxidative Cyclization is Blocked

Apoorva Bhatt, Christian B. W. Stark, Barbara M. Harvey, Andrew R. Gallimore, Yuliya A. Demydchuk, Jonathan B. Spencer, James Staunton, Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 120 KB

english, 2005

27

Insights into Lasalocid A Ring Formation by Chemical Chain Termination In Vivo

Dr. Manuela Tosin, Luke Smith, Prof. Peter F. Leadlay

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 598 KB

english, 2011

28

Biochemistry with a human face Biochemistry (1991). By Mary K. Campbell. Saunders College Publishing, Philadelphia. 622pp. $43

Journal:

Year:

1992

Language:

english

File:

PDF, 278 KB

english, 1992

29

Catalytically Active Tetramodular 6-Deoxyerythonolide B Synthase Fusion Proteins

Corinne M. Squire, Rebecca J. M. Goss, Hui Hong, Peter F. Leadlay, James Staunton

Journal:

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

30

New Rapamycin Derivatives by Precursor-Directed Biosynthesis

Philip A. S. Lowden, Günter A. Böhm, Su Metcalfe, James Staunton, Peter F. Leadlay

Journal:

Year:

2004

Language:

english

File:

PDF, 110 KB

english, 2004

31

Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea

Kira J. Weissman, Hui Hong, Markiyan Oliynyk, Alexis P. Siskos, Peter F. Leadlay

Journal:

Year:

2004

Language:

english

File:

PDF, 358 KB

english, 2004

32

Engineered Biosynthesis of Phenyl-Substituted Polyketides

José Garcia-Bernardo, Longkuan Xiang, Hui Hong, Bradley S. Moore, Peter F. Leadlay

Journal:

Year:

2004

Language:

english

File:

PDF, 113 KB

english, 2004

33

A Novel Mycolactone from a Clinical Isolate of Mycobacterium ulcerans Provides Evidence for Additional Toxin Heterogeneity as a Result of Specific Changes in the Modular Polyketide Synthase

Hui Hong, Jonathan B. Spencer, Jessica L. Porter, Peter F. Leadlay, Tim Stinear

Journal:

Year:

2005

Language:

english

File:

PDF, 273 KB

english, 2005

34

Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin

Barbara M. Harvey, Hui Hong, Michelle A. Jones, Zoë A. Hughes-Thomas, Rebecca M. Goss, Michelle L. Heathcote, Victor M. Bolanos-Garcia, Wolfgang Kroutil, James Staunton, Peter F. Leadlay, Jonathan B.

Journal:

Year:

2006

Language:

english

File:

PDF, 353 KB

english, 2006

35

Cover Picture: A Novel Mycolactone from a Clinical Isolate of Mycobacterium ulcerans Provides Evidence for Additional Toxin Heterogeneity as a Result of Specific Changes in the Modular Polyketide Synthase (ChemBioChem 4/2005)

Hui Hong, Jonathan B. Spencer, Jessica L. Porter, Peter F. Leadlay, Tim Stinear

Journal:

Year:

2005

File:

PDF, 42 KB

2005

36

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

Hui Hong, Tim Stinear, Jessica Porter, Caroline Demangel, Peter F. Leadlay

Journal:

Year:

2007

Language:

english

File:

PDF, 285 KB

english, 2007

37

Glyceryl-S-Acyl Carrier Protein as an Intermediate in the Biosynthesis of Tetronate Antibiotics

Yuhui Sun, Hui Hong, Fraser Gillies, Jonathan B. Spencer, Peter F. Leadlay

Journal:

Year:

2008

Language:

english

File:

PDF, 1.35 MB

english, 2008

38

Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic

Yuliya Demydchuk, Yuhui Sun, Hui Hong, James Staunton, Jonathan B. Spencer, Peter F. Leadlay

Journal:

Year:

2008

Language:

english

File:

PDF, 814 KB

english, 2008

39

Covalent Linkage Mediates Communication between ACP and TE Domains in Modular Polyketide Synthases

Lucky Tran, Manuela Tosin, Jonathan B. Spencer, Peter F. Leadlay, Kira J. Weissman

Journal:

Year:

2008

Language:

english

File:

PDF, 797 KB

english, 2008

40

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

Laurenz Kellenberger, Ian S. Galloway, Guido Sauter, Günter Böhm, Ulf Hanefeld, Jesús Cortés, James Staunton, Peter F. Leadlay

Journal:

Year:

2008

Language:

english

File:

PDF, 412 KB

english, 2008

41

Improved Catalytic Activity of a Purified Multienzyme from a Modular Polyketide Synthase after Coexpression with Streptomyces Chaperonins in Escherichia coli.

Lorena Betancor, María-José Fernández , Kira J. Weissman , Peter F. Leadlay

Journal:

Year:

2008

Language:

english

File:

PDF, 350 KB

english, 2008

42

Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure

Luke Smith, Hui Hong, Jonathan B. Spencer , Peter F. Leadlay

Journal:

Year:

2008

Language:

english

File:

PDF, 500 KB

english, 2008

43

Synthetic Chain Terminators Off-Load Intermediates from a Type I Polyketide Synthase

Manuela Tosin, Lorena Betancor, Elaine Stephens, W. M. Ariel Li, Jonathan B. Spencer, Peter F. Leadlay

Journal:

Year:

2010

Language:

english

File:

PDF, 274 KB

english, 2010

44

Stereoselectivity of Isolated Dehydratase Domains of the Borrelidin Polyketide Synthase: Implications for cis Double Bond Formation

Dr. Olivia Vergnolle, Dr. Frank Hahn, Dr. Abel Baerga-Ortiz, Prof. Dr. Peter F. Leadlay, Dr. Jennifer N. Andexer

Journal:

Year:

2011

Language:

english

File:

PDF, 319 KB

english, 2011

45

An Additional Dehydratase-Like Activity is Required for Lankacidin Antibiotic Biosynthesis

Dr. Jeroen S. Dickschat , Dr. Olivia Vergnolle , Dr. Hui Hong, Dr. Stephen Garner, Susanna R. Bidgood, Hannah C. Dooley, Prof. Zixin Deng, Prof. Peter F. Leadlay, Prof. Yuhui Sun

Journal:

Year:

2011

Language:

english

File:

PDF, 233 KB

english, 2011

46

A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster

Marie E. Yurkovich, Petros A. Tyrakis, Dr. Hui Hong, Prof. Yuhui Sun, Dr. Markiyan Samborskyy, Dr. Kohei Kamiya , Prof. Peter F. Leadlay

Journal:

Year:

2012

Language:

english

File:

PDF, 751 KB

english, 2012

47

ChemInform Abstract: Enantiospecific Synthesis of Tetrasubstituted δ-Lactones.

Annabel L. Wilkinson, Ulf Hanefeld, Barrie Wilkinson, Peter F. Leadlay, James Staunton

Journal:

Year:

1999

File:

PDF, 30 KB

1999

48

ChemInform Abstract: Novel Erythromycins from a Recombinant Saccharopolyspora erythraea Strain NRRL 2338 pIG1. Part 1. Fermentation, Isolation, and Biological Activity.

Michael S. Pacey, John P. Dirlam, Roderick W. Geldart, Peter F. Leadlay, Hamish A. I. McArthur, Ellen L. McCormick, Robert A. Monday, Thomas N. O'Connell, James Staunton, Toby J. Winchester

Journal:

Year:

1999

File:

PDF, 30 KB

1999

49

A Novel Erythromycin, 6-Desmethyl Erythromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase.

Hrvoje Petkovic, Rachel E. Lill, Rose M. Sheridan, Barrie Wilkinson, Ellen L. McCormick, Hamish A. I. McArthur, James Staunton, Peter F. Leadlay, Steven G. Kendrew

Journal:

Year:

2003

File:

PDF, 70 KB

2003

50

Identification of a Phosphopantetheinyl Transferase for Erythromycin Biosynthesis in Saccharopolyspora erythraea.

Kira J. Weissman, Hui Hong, Markiyan Oliynyk, Alexis P. Siskos, Peter F. Leadlay

Journal:

Year:

2004

File:

PDF, 50 KB

2004